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In preclinical studies, CJC-1295 (no DAC) acts as a selective GHRH receptor agonist. It binds to receptors located on pituitary somatotroph cells, activating Gs-protein signaling pathways. This interaction increases intracellular cAMP levels and activates protein kinase A, triggering pulsatile release of endogenous growth hormone. The peptide has a short half-life of approximately 30 minutes, producing brief and controlled GH pulses that closely resemble natural hypothalamic and pituitary regulation. Unlike DAC variants, it does not cause prolonged GH elevation. Laboratory studies demonstrate increased GH pulse amplitude and IGF‑1 upregulation without receptor desensitization during short exposure periods.
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This product is intended as a research chemical only. This designation allows the use of research chemicals strictly for in vitro (out of the body) testing, and laboratory experimentation only. Any introduction into human or animal bodies is strictly forbidden by law. This product is not a drug, and may not be misbranded, mishandled, or misused as a drug.
Research
Growth Hormone Deficiency
In adults, Growth Hormone (GH) maintains bone density, increases lean muscle mass, and reduces body fat.
Metabolism Regulation: Stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which helps manage fat, sugar, and protein metabolism.
Protein Synthesis: Enhances amino acid uptake, boosting muscle growth and repairing tissues.
Energy Utilization: Promotes the breakdown of fats (lipolysis), allowing them to be used for energy rather than stored.
Connective Tissue Repair: Boosts collagen synthesis to strengthen ligaments, tendons, and cartilage.
Immune System Support: Supports the function of immune cells, including T-cells and cytokines.
GH levels fluctuate daily, peaking during puberty. It works by stimulating the liver and other tissues to produce IGF-1, which directly induces growth.
CJC-1295 has been studied for its affect to increase GH and IGF-1 in humans. [1]