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In experimental models, Selank influences multiple neurotransmitter systems. It decreases enkephalinase activity, stabilizing endogenous enkephalins and augmenting opioid tone. It alters serotonin metabolism through inhibition of enkephalin-degrading enzymes and modulation of 5-HT turnover. GABAergic transmission is influenced, resulting in anxiolytic-like effects without concomitant sedative effects in animal behavioral models.
Selank enhances BDNF expression in hippocampal and cortical regions, supporting research on neuroplasticity. In stress models, it exhibits immunomodulatory activity by modulating IL-6 (interleukin-6), IL-10, and other cytokines. These combined mechanisms are explored in anxiety, cognition, stress resilience, and neuroinflammation research.
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This product is intended as a research chemical only. This designation allows the use of research chemicals strictly for in vitro (out of the body) testing, and laboratory experimentation only. Any introduction into human or animal bodies is strictly forbidden by law. This product is not a drug, and may not be misbranded, mishandled, or misused as a drug.
Research
Preclinical studies have investigated Selank in anxiety, stress, and cognitive function models. Selank decreased anxiety-like behavior in rodent behavioral tests such as elevated plus-maze and open-field without affecting motor function or causing sedation. It restored serotonin and enkephalin activity to normal levels in midbrain regions affected by chronic stress or immobilization. [1]
Selank increased acquisition and retention in passive avoidance and Morris water maze paradigms, possibly through upregulation of BDNF in learning and memory models. [2]
Immunomodulatory effects include modulation of IL-6/IL-10 balance and reduction of pro-inflammatory markers in acute traumatic stress–induced immune suppression. [3]
In vitro studies suggest Selank affects cytokine release and promotes neuroprotection in glial cells. [4]
Selank remains investigational. No large-scale human trials have been conducted, and it is not approved for any therapeutic purpose. Ongoing research continues to evaluate its potential in anxiety, cognitive, and neuroinflammatory models.